Hallmarks of Cancer: New Dimensions. *k'D%}N:
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast c]jK
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complexity of cancer phenotypes and genotypes into a provisional set of underly- )qs>Z?7
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have VyK]:n<5Q
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- + jD?h-]
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- S8;Dk@rr(y
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate H
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the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added 01Bs7@"+
to the roster of functionally important cell types in the tumor microenvironment.
