Hallmarks of Cancer: New Dimensions. ] '5Xjc x
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast q/@2=$]hH3
complexity of cancer phenotypes and genotypes into a provisional set of underly- x,C8):\t`B
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have %`i*SF(gV
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- d5^^h< '
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- v~ >Bbe
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate )K[\j?
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added 4aArxJ
to the roster of functionally important cell types in the tumor microenvironment.
