Hallmarks of Cancer: New Dimensions. o)^ W
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The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast W I MBw mg
complexity of cancer phenotypes and genotypes into a provisional set of underly- ( N};.DB1Y
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have Jww#zEK
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- w D r/T3
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- hh&$xlO)(v
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate &} `a"tYr
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added x \8|A
to the roster of functionally important cell types in the tumor microenvironment.
