Hallmarks of Cancer: New Dimensions. }x1IFTa!
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast K-C,+
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complexity of cancer phenotypes and genotypes into a provisional set of underly- o#) !b:/
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have ]r1{%:8
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- Nt-SC
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rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- Ur (o &,
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate %d J>8.jW@
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added PEt8,,x<"
to the roster of functionally important cell types in the tumor microenvironment.
