Hallmarks of Cancer: New Dimensions. <Dm6CH
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast +crAkb}i
complexity of cancer phenotypes and genotypes into a provisional set of underly- sTG+ c E
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have >.{
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emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- eaX`S.!jR
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- qh7o;x~,
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate $#RD3#=?u
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added ]`.
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to the roster of functionally important cell types in the tumor microenvironment.
