Hallmarks of Cancer: New Dimensions. ,%)O/{p_
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast yx0wR
complexity of cancer phenotypes and genotypes into a provisional set of underly- j) G< PW
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have Qt-7jmZw1
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- Db:^Omw o
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- srzlr-J
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate Y -yozt
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added -!o*A>
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to the roster of functionally important cell types in the tumor microenvironment.
