Hallmarks of Cancer: New Dimensions. : p*ojl|
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast /^es0$Co.
complexity of cancer phenotypes and genotypes into a provisional set of underly- bl!f5RO S(
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have `mHOgS>|
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- X?k V1
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- wshp{ y
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate :6P c m3
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added `__?7"p
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to the roster of functionally important cell types in the tumor microenvironment.
