Hallmarks of Cancer: New Dimensions. `,Xb8^M2
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast }$<^wt
complexity of cancer phenotypes and genotypes into a provisional set of underly- ?Q;kZmQl
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have </|)"OD9
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- YWSz84d
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- {:,_A
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate b~jIv:9T
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added !O 4<I_EY{
to the roster of functionally important cell types in the tumor microenvironment.
