肿瘤方面考博必读文献

Hallmarks of Cancer: New Dimensions. zHX7%x,Cq  
      The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast mhgvN-? "h  
complexity of cancer phenotypes and genotypes into a provisional set of underly- I]-"Tw  
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have
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emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- 'j9x(T1M1  
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- MMy\u) 4  
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate ++!'6!l  
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added <xlyk/  
to the roster of functionally important cell types in the tumor microenvironment.