Hallmarks of Cancer: New Dimensions. \M`fkR,,'
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast %S<( z5
complexity of cancer phenotypes and genotypes into a provisional set of underly- Af"vSL
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have #FV( a ~
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- SbW6O_
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- O(E- ox~q
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate W=~H_ L?/
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added XOy#? X/`
to the roster of functionally important cell types in the tumor microenvironment.
