肿瘤方面考博必读文献

Hallmarks of Cancer: New Dimensions. "R^0e Nv$  
      The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast ,'%*z  
complexity of cancer phenotypes and genotypes into a provisional set of underly- ~n;U5hcB  
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have KJi8LM  
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- N) '|l0x0  
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- h~5gHx/a  
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate ,:xses*7  
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added l,ic-Y1  
to the roster of functionally important cell types in the tumor microenvironment.