Hallmarks of Cancer: New Dimensions. 3/M.0}e
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast @Z\2* 1y6
complexity of cancer phenotypes and genotypes into a provisional set of underly- |k-XBp
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have {w`:KR6o7
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- Na!za'qk[o
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- "2HY5 AE
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate W7G9Kx1Y
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added P0\eB S
to the roster of functionally important cell types in the tumor microenvironment.
