Hallmarks of Cancer: New Dimensions. m<@ z}%v-
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast ];F tS>\x
complexity of cancer phenotypes and genotypes into a provisional set of underly- e7k%6'@
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have S; /. %
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- 5PiOH"!19
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- jk7 0u[\
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate g22gIj]
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added y4jU{,
to the roster of functionally important cell types in the tumor microenvironment.
