Hallmarks of Cancer: New Dimensions. h9#)Eo
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast -V;BkE76
complexity of cancer phenotypes and genotypes into a provisional set of underly- 0!7p5
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have -
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emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- ,?k1if(0[
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- {]Hv*{ ]
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate OZnKJ<
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added &i.sSqSI5
to the roster of functionally important cell types in the tumor microenvironment.
