Hallmarks of Cancer: New Dimensions. .C]V==z`[4
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast JNQiCK,)}M
complexity of cancer phenotypes and genotypes into a provisional set of underly- l?>sLKo9
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have g[VVxp!C<
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- U) tqo _
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- /:]`TlAb,
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate ]= 2w Q8
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added "=cWcztiP
to the roster of functionally important cell types in the tumor microenvironment.
