Hallmarks of Cancer: New Dimensions. }(f,~?CP]
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast &?uzJx~
complexity of cancer phenotypes and genotypes into a provisional set of underly- k~W;TCJs
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have tCF0Ah
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- #Fb0;H9`
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- %te'J G<
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate "' i [~
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added b(.o|d /P
to the roster of functionally important cell types in the tumor microenvironment.
