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要求简练,精确 ]@l;;Sp
Compassionate use of bevacizumab (Avastin) in children and young adults with raM{!T
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refractory or recurrent solid tumors. ~SwGZ
Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma =vL
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xenografts results in improved delivery and efficacy of systemically administered %)e&"
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chemotherapy. Z[kVVE9b?
Proteomics Approaches to the Systems Biology of Cardiovascular Diseases | }d+BD
Pre- and post-natal treatment of hemophagocytic lymphohistiocytosis. 1WI^RlWd(
Lack of early bevacizumab-related skeletal radiographic changes in children with /5?tXH
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neuroblastoma. k?_uv
Interleukin-4 activates androgen receptor through CBP/p300 ]'z 5%'
Trisomy 8 in an allogeneic stem cell transplant recipient representative of a - P4X@s_;
donor-derived constitutional abnormality. >ffQ264g=i
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy pO2XQYhrY
T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase- d 0:;IUG
High-dose conformal RT improves tumor control in patients with prostate cancer
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Vitamin D concentration does not affect the risk of prostate cancer -I~\
Liver resection with salvage transplantation for hepatocellular carcinoma cY|@s?3NND
The impact of histopathologic diagnosis on the proper management of testis neoplasms WT1d'@
LY
Prostate stem cell antigen is associated with diffuse-type gastric cancer mC'<Ov<eJ
Multiple myeloma: high-risk immunophenotypes identified g
c W'
Increased c-kit expression predicts poor outcome in acute myeloid leukemia \CYKj_c
Global Analysis of the Meiotic Crossover Landscape 5zF$Q {3
Serum Response Factor Is Required for Sprouting Angiogenesis and Vascular Integrity sTxbh2
Integrin Trafficking Regulated by Rab21 Is Necessary for Cytokinesis k
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Reduced Translocation of Nascent Prion Protein During ER Stress Contributes to 7<LCX{Uw
Neurodegeneration c(s: f@ 1
Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: t*Z4&Sy^
Results of the randomized, double-blind, placebo-controlled INEF study. 26=G%F
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Global experiences with vardenafil in men with erectile dysfunction and underlying p }3$7CR/
conditions. 43!E> mq
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Noninvasive cardiac imaging: implications for risk assessment in adolescents and young $IJ"fs
adults. xr31<4B
Transforming growth factor beta1 T29C gene polymorphism and hypertension: R'^J#"[
Relationship with cardiovascular and renal damage. |Pv)&'B"
A comparison of hormone therapies on the urinary excretion of prostacyclin and HHT8_c'CC#
thromboxane A2. <_SdW 5BF<
Repair of an infected aortic aneurysm using an aortic allograft and a venous autograft: yB4
eUa!1
Report of a case. Y"TrF(C
Circulating Leptin and Stress-induced Cardiovascular Activity in Humans. a._>?rVy
Effects of aspirin dose on ischaemic events and bleeding after percutaneous coronary 3s#/d,+
intervention: insights from the PCI-CURE study. m1RjD$fM
Long-term cardiovascular outcomes following ischemic heart disease in patients with and (XV+aQ \A
without peripheral vascular disease. (Y
Reduced renal function and sleep-disordered breathing in community-dwelling elderly KBgFS%-W
men. Tzfk_h3hE
Intracoronary pharmacotherapy in the management of coronary microvascular
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dysfunction. "71Y{WQ
Inhibition of platelet aggregation by combined therapy with aspirin and cilostazol after
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off-pump coronary artery bypass surgery. -gv[u,R
Inhibition of CCR2 Ameliorates Insulin Resistance and Hepatic Steatosis in db/db Mice %
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Abstract 要求简洁,连贯 /mK]O7O7
The acquisition of metastatic ability by tumor cells is considered a late event in the dA0
o{[o=
evolution of malignant tumors. We report that untransformed mouse mammary cells that +a^0Q
F-7
have been engineered to express the inducible oncogenic transgenes MYC and KrasD12, or )
IKqO:@
polyoma middle T, and introduced into the systemic circulation of a mouse can bypass zG<>-?q~'
transformation at the primary site and develop into metastatic pulmonary lesions upon
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immediate or delayed oncogene induction. Therefore, previously untransformed |wyua@2
mammary cells may establish residence in the lung once they have entered the pJ/{X=y
bloodstream and may assume malignant growth upon oncogene activation. Mammary _!%@V=
cells lacking oncogenic transgenes displayed a similar capacity for long-term residence in )00jRuF
the lungs but did not form ectopic tumors. =P,pW
Almost two decades after CFTR was identified as the gene responsible for cystic fibrosis yjM!M|
(CF), we still lack answers to many questions about the pathogenesis of the disease, and it 3w+ +F@(
remains incurable. Mice with a disrupted CFTR gene have greatly facilitated CF studies, 6
dYa07
but the mutant mice do not develop the characteristic manifestations of human CF, 8]WcW/1r !
including abnormalities of the pancreas, lung, intestine, liver, and other organs. Because Bf
Q#5
pigs share many anatomical and physiological features with humans, we generated pigs n%6=w9.%c
with a targeted disruption of both CFTR alleles. Newborn pigs lacking CFTR exhibited G'Uq595'-
defective chloride transport and developed meconium ileus, exocrine pancreatic ;.7]zn.X]2
destruction, and focal biliary cirrhosis, replicating abnormalities seen in newborn humans Iz&<rL;s
3 *]ME]2qP
with CF. The pig model may provide opportunities to address persistent questions about G_xql_QR
CF pathogenesis and accelerate discovery of strategies for prevention and treatment. #/)U0IR)
Variable lymphocyte receptors (VLRs) rather than antibodies play the primary role in %< Jj[F
recognition of antigens in the adaptive immune system of jawless vertebrates. \mw5
~Rf;
Combinatorial assembly of leucine-rich repeat (LRR) gene segments achieves the H h%|}*f_,
required repertoire for antigen recognition. We have determined a crystal structure for a U \jFB*U
VLR-antigen complex, VLR RBC36 in complex with the H-antigen trisaccharide from j{HIdP
human blood type O erythrocytes, at 1.67 angstrom resolution. RBC36 binds the 5E2T*EXSh
H-trisaccharide on the concave surface of the LRR modules of the solenoid structure ZsG
J[
where three key hydrophilic residues, multiple van der Waals interactions, and the highly *?o 'sTH
variable insert of the carboxyl-terminal LRR module determine antigen recognition and EH]qYF.
specificity. The concave surface assembled from the most highly variable regions of the vh^?M#\
LRRs, along with diversity in the sequence and length of the highly variable insert, can MFqb_q+
account for the recognition of diverse antigens by VLRs. $Eo-58<q
A 51-year-old man with a diagnosis of myelodysplasia and non-Hodgkin's lymphoma cY.5z:7u~v
underwent an unmatched allogenic bone marrow transplantation and was treated A9LVS&52
posttransplant with chronic immunosuppressive medication. Eight months following "f-HOd\=
transplantation, he presented with progressive dysarthria, cognitive and visual decline. qG#ZYcVec
Evaluation included brain magnetic resonance (MR) imaging demonstrating multifocal (_fovV=
areas of increased T2 and FLAIR (fluid attenuated inversion recovery) signals involving i L'j9_w,
the left frontal, parietal, and occipital lobes. The MR lesions demonstrated diffuse ;;Jx1Q
increased signal on DWI (diffusion-weighted images) and normal to low signal on ADC ;V84Dy#b
(apparent diffusion coefficients). Contrast-enhanced T1 images were unremarkable. `|4k>5k
Lumbar puncture revealed a mild elevation in cerebrospinal fluid (CSF) protein. CSF 2FEi-m}
PCR assay for viral DNA fragments were negative on two occasions. Serum serology for M/YS%1
HIV was negative as well. A brain biopsy was subsequently performed. The clinical and HaQox.v%
neuroimaging differential diagnoses as well as neuropathologic correlation are presented. LmP pt3[
In vitro-generated mesenchymal stem cells (MSCs) initially attracted interest for their M} Mgz
ability to undergo differentiation toward cells of different lineages. ,
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These results suggested that ~g*5."-i
However, there are still obstacles in W?du ]
The major challenge for successful drug development is identifying delivery strategies rg I Z
that can be translated to the clinic. ^O&&QR