Hallmarks of Cancer: New Dimensions. P!5Z]+B#
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast Pfm*<,'x"[
complexity of cancer phenotypes and genotypes into a provisional set of underly- [ 4Y[?)7
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have \F[
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emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- Cgo9rC~]
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- .U<F6I:<md
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate ,pn ) >
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added 3#9 uEDdE
to the roster of functionally important cell types in the tumor microenvironment.
