Hallmarks of Cancer: New Dimensions. SY^t} A7:/
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast ?_v akJ
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complexity of cancer phenotypes and genotypes into a provisional set of underly- X4E%2-m@'
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have uPG4V 2
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- A?%H=>v $
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- W$OG( m!W>
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate C=It* j5 5
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added ~ZEmULKkR
to the roster of functionally important cell types in the tumor microenvironment.
