Hallmarks of Cancer: New Dimensions. R6BbkYWrX
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast }~|`h1JF
complexity of cancer phenotypes and genotypes into a provisional set of underly- 7Y[ q)
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ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have 3vcyes-U
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- P7b"(G%
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- m3Wc};yE*Q
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate Z P!.C&O
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added g*My1+J!
to the roster of functionally important cell types in the tumor microenvironment.
