Hallmarks of Cancer: New Dimensions. l#bE _PD;
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast ,4--3 MU
complexity of cancer phenotypes and genotypes into a provisional set of underly- '@dk3:3t
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have r&3EM[*Iw
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- -]<<}@N F
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- @id!F<+%oD
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate IN 7Cpg~9%
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added G3dA`3
to the roster of functionally important cell types in the tumor microenvironment.
