肿瘤方面考博必读文献

Hallmarks of Cancer: New Dimensions. Q}G2f4  
      The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast 
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complexity of cancer phenotypes and genotypes into a provisional set of underly- ?e m8nZ'  
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have " F}dZ  
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- qw$9i.Z  
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- 064k;|>D  
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate Yj'9|4%+|  
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added U3C"o|   
to the roster of functionally important cell types in the tumor microenvironment.