Hallmarks of Cancer: New Dimensions. A %w9Da?B
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast rfV'EjiM}
complexity of cancer phenotypes and genotypes into a provisional set of underly- -jQ*r$iRE
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have HDm]njF%qQ
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- q<AnWNheE
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- P" c@V, .
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate ?K$&|w%{3
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added @$slGY
to the roster of functionally important cell types in the tumor microenvironment.
