Hallmarks of Cancer: New Dimensions. 8 tQL$CbO
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast BO7HJF)a
complexity of cancer phenotypes and genotypes into a provisional set of underly- 2p\xgAW?
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have gDLS)4^w
emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- ."^\1N(.n
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- J( XD wt
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate G"J
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the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added !37I2*+4
to the roster of functionally important cell types in the tumor microenvironment.
