肿瘤方面考博必读文献

Hallmarks of Cancer: New Dimensions. /{lls2ycW%  
      The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast (\G~S 4  
complexity of cancer phenotypes and genotypes into a provisional set of underly- kys?%Y1  
ing principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have u5lj+
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emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and dis- `VHm,g2  
rupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogram- EV9m\'=j  
ming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate D%Wr/6X  
the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added 7|2:;5:U  
to the roster of functionally important cell types in the tumor microenvironment.